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Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling
β2 integrins are the main adhesion molecules in neutrophils and other leukocytes and are rapidly activated by inside-out signaling, which results in conformational changes that are transmitted through the transmembrane domain (TMD). Here, we investigated the biologic effect of introducing a proline...
Enregistré dans:
| Publié dans: | J Leukoc Biol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6987018/ https://ncbi.nlm.nih.gov/pubmed/31475386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.1HI0219-073RR |
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