The Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation

BACKGROUND: Hypervitaminosis A, alcoholism or medical treatment for acute promyelocytic leukaemia may cause unphysiologically high accumulation of all-trans retinoic acid (ATRA), which could inhibit osteoblastogenesis, thereby triggering osteoporosis. We have shown that bone morphogenetic protein-2...

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Dades bibliogràfiques
Publicat a:Drug Des Devel Ther
Autors principals: Wang, Siqian, Bi, Wenjuan, Liu, Yi, Cheng, Jiayi, Sun, Wei, Wu, Gang, Xu, Xin
Format: Artigo
Idioma:Inglês
Publicat: Dove 2020
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985983/
https://ncbi.nlm.nih.gov/pubmed/32158187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S215786
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