Decreased uterine vascularization and uterine arterial expansive remodeling with reduced matrix metalloproteinase-2 and -9 in hypertensive pregnancy

Normal pregnancy involves extensive remodeling of uterine and spiral arteries and matrix metalloproteinases (MMPs)-mediated proteolysis of extracellular matrix (ECM). Preeclampsia is characterized by hypertension in pregnancy (HTN-Preg) and intrauterine growth restriction (IUGR) with unclear mechani...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Lin, Chen, He, Hong, Cui, Ning, Ren, Zongli, Zhu, Minglin, Khalil, Raouf A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985805/
https://ncbi.nlm.nih.gov/pubmed/31834839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00602.2019
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