Mutations in Ribosomal Protein RplA or Treatment with Ribosomal Acting Antibiotics Activates Production of Aminoglycoside Efflux Pump SmeYZ in Stenotrophomonas maltophilia

Aminoglycoside resistance in Stenotrophomonas maltophilia is multifactorial, but the most significant mechanism is overproduction of the SmeYZ efflux system. By studying laboratory-selected mutants and clinical isolates, we show here that damage to the 50S ribosomal protein L1 (RplA) activates SmeYZ...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Calvopiña, Karina, Dulyayangkul, Punyawee, Avison, Matthew B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2020
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985731/
https://ncbi.nlm.nih.gov/pubmed/31712205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01524-19
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