Linker Editing of Pneumococcal Lysin ClyJ Conveys Improved Bactericidal Activity

Streptococcus pneumoniae is a leading human pathogen uniquely characterized by choline moieties on the bacterial surface. Our previous work reported a pneumococcus-specific chimeric lysin, ClyJ, which combines the CHAP (cysteine, histidine-dependent amidohydrolase/peptidase) enzymatically active dom...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Yang, Hang, Luo, Dehua, Etobayeva, Irina, Li, Xiaohong, Gong, Yujing, Wang, Shujuan, Li, Qiong, Xu, Poshi, Yin, Wen, He, Jin, Nelson, Daniel C., Wei, Hongping
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985707/
https://ncbi.nlm.nih.gov/pubmed/31767724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01610-19
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