Analysis of the Potential for N(4)-Hydroxycytidine To Inhibit Mitochondrial Replication and Function

N(4)-Hydroxycytidine (NHC) is an antiviral ribonucleoside analog that acts as a competitive alternative substrate for virally encoded RNA-dependent RNA polymerases. It exhibits measurable levels of cytotoxicity, with 50% cytotoxic concentration values ranging from 7.5 μM in CEM cells and up to >1...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Sticher, Zachary M., Lu, Gaofei, Mitchell, Deborah G., Marlow, Joshua, Moellering, Levi, Bluemling, Gregory R., Guthrie, David B., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985706/
https://ncbi.nlm.nih.gov/pubmed/31767721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01719-19
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