Suppression of AMP‐activated protein kinase reverses osteoprotegerin‐induced inhibition of osteoclast differentiation by reducing autophagy

OBJECTIVES: Osteoclasts (OC) are unique terminally differentiated cells whose primary function is bone resorption. We previously showed that osteoprotegerin (OPG) inhibits OC differentiation in vitro by enhancing autophagy via the adenosine monophosphate‐activated protein kinase (AMPK)/mTOR/p70S6K s...

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Detalhes bibliográficos
Publicado no:Cell Prolif
Main Authors: Tong, Xishuai, Zhang, Chuang, Wang, Dong, Song, Ruilong, Ma, Yonggang, Cao, Ying, Zhao, Hongyan, Bian, Jianchun, Gu, Jianhong, Liu, Zongping
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985670/
https://ncbi.nlm.nih.gov/pubmed/31696568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12714
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