Osteoprotegerin Induces Apoptosis of Osteoclasts and Osteoclast Precursor Cells via the Fas/Fas Ligand Pathway

Osteoprotegerin (OPG) is known to inhibit differentiation and activation of osteoclasts (OCs) by functioning as a decoy receptor blocking interactions between RANK and RANKL. However, the exact role of OPG in the survival/apoptosis of OCs remains unclear. OPG caused increased rates of apoptosis of b...

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Udgivet i:PLoS One
Main Authors: Liu, Wei, Xu, Chao, Zhao, Hongyan, Xia, Pengpeng, Song, Ruilong, Gu, Jianhong, Liu, Xuezhong, Bian, Jianchun, Yuan, Yan, Liu, Zongping
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646684/
https://ncbi.nlm.nih.gov/pubmed/26571489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142519
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