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Cyclooxygenase-2 Induced the β-Amyloid Protein Deposition and Neuronal Apoptosis Via Upregulating the Synthesis of Prostaglandin E(2) and 15-Deoxy-Δ(12,14)-prostaglandin J(2)
Elevated levels of cyclooxygenase-2 (COX-2) and prostaglandins (PGs) have been shown to be involved in the pathogenesis of Alzheimer’s disease. Analysis of the underlying mechanisms elucidated a function of sequential PGE(2) and PGD(2) synthesis in regulating β-amyloid protein (Aβ) deposition by mod...
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| Publicado no: | Neurotherapeutics |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6985346/ https://ncbi.nlm.nih.gov/pubmed/31392591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00770-z |
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