Cancer Cells Expressing Oncogenic Rat Sarcoma Show Drug-Addiction Toward Epidermal Growth Factor Receptor Antibodies Mediated by Sustained MAPK Signaling

Epidermal growth factor receptor (EGFR) antibodies may have detrimental effects in patients with metastatic colorectal cancer expressing oncogenic Rat sarcoma (RAS). Since a significant number of patients acquire RAS-mediated resistance during EGFR-directed treatment, understanding the molecular mec...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Oncol
Prif Awduron: Tintelnot, Joseph, Metz, Sina, Trentmann, Marie, Oberle, Anna, von Wenserski, Lisa, Schultheiß, Christoph, Braig, Friederike, Kriegs, Malte, Fehse, Boris, Riecken, Kristoffer, Bokemeyer, Carsten, Stein, Alexander, Binder, Mascha
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2020
Pynciau:
Oncology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985072/
https://ncbi.nlm.nih.gov/pubmed/32039027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01559
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