Cancer Cells Expressing Oncogenic Rat Sarcoma Show Drug-Addiction Toward Epidermal Growth Factor Receptor Antibodies Mediated by Sustained MAPK Signaling

Epidermal growth factor receptor (EGFR) antibodies may have detrimental effects in patients with metastatic colorectal cancer expressing oncogenic Rat sarcoma (RAS). Since a significant number of patients acquire RAS-mediated resistance during EGFR-directed treatment, understanding the molecular mec...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Tintelnot, Joseph, Metz, Sina, Trentmann, Marie, Oberle, Anna, von Wenserski, Lisa, Schultheiß, Christoph, Braig, Friederike, Kriegs, Malte, Fehse, Boris, Riecken, Kristoffer, Bokemeyer, Carsten, Stein, Alexander, Binder, Mascha
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985072/
https://ncbi.nlm.nih.gov/pubmed/32039027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01559
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