Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL

Bone homeostasis critically relies on the RANKL-RANK-OPG axis which can be targeted by the fully human monoclonal antibody denosumab in conditions with increased bone resporption such as bone metastases. The binding site and therefore the molecular mechanism by which this antibody inhibits RANKL has...

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Detalhes bibliográficos
Main Authors: Schieferdecker, Aneta, Voigt, Mareike, Riecken, Kristoffer, Braig, Friederike, Schinke, Thorsten, Loges, Sonja, Bokemeyer, Carsten, Fehse, Boris, Binder, Mascha
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196153/
https://ncbi.nlm.nih.gov/pubmed/25138051
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