Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL

Bone homeostasis critically relies on the RANKL-RANK-OPG axis which can be targeted by the fully human monoclonal antibody denosumab in conditions with increased bone resporption such as bone metastases. The binding site and therefore the molecular mechanism by which this antibody inhibits RANKL has...

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Bibliografiska uppgifter
Huvudupphovsmän: Schieferdecker, Aneta, Voigt, Mareike, Riecken, Kristoffer, Braig, Friederike, Schinke, Thorsten, Loges, Sonja, Bokemeyer, Carsten, Fehse, Boris, Binder, Mascha
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2014
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196153/
https://ncbi.nlm.nih.gov/pubmed/25138051
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