Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL

Bone homeostasis critically relies on the RANKL-RANK-OPG axis which can be targeted by the fully human monoclonal antibody denosumab in conditions with increased bone resporption such as bone metastases. The binding site and therefore the molecular mechanism by which this antibody inhibits RANKL has...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Schieferdecker, Aneta, Voigt, Mareike, Riecken, Kristoffer, Braig, Friederike, Schinke, Thorsten, Loges, Sonja, Bokemeyer, Carsten, Fehse, Boris, Binder, Mascha
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196153/
https://ncbi.nlm.nih.gov/pubmed/25138051
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky