The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II

Macroautophagy/autophagy has emerged as a central process in lymphocyte homeostasis, activation and differentiation. Based on our finding that the p66 isoform of SHC1 (p66SHC) pro-apoptotic ROS-elevating SHC family adaptor inhibits MTOR signaling in these cells, here we investigated the role of p66S...

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Publicat a:Autophagy
Autors principals: Onnis, Anna, Cianfanelli, Valentina, Cassioli, Chiara, Samardzic, Dijana, Pelicci, Pier Giuseppe, Cecconi, Francesco, Baldari, Cosima T
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984773/
https://ncbi.nlm.nih.gov/pubmed/30109811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1505153
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