The Shc Family Protein Adaptor, Rai, Negatively Regulates T Cell Antigen Receptor Signaling by Inhibiting ZAP-70 Recruitment and Activation

Rai/ShcC is a member of the Shc family of protein adaptors expressed with the highest abundance in the central nervous system, where it exerts a protective function by coupling neurotrophic receptors to the PI3K/Akt survival pathway. Rai is also expressed, albeit at lower levels, in other cell types...

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Detalhes bibliográficos
Main Authors: Ferro, Micol, Savino, Maria Teresa, Ortensi, Barbara, Finetti, Francesca, Genovese, Luca, Masi, Giulia, Ulivieri, Cristina, Benati, Daniela, Pelicci, Giuliana, Baldari, Cosima T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248456/
https://ncbi.nlm.nih.gov/pubmed/22242145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029899
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