Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs

Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial anion carriers (anionophores). Here, we screened 22 anionophores for biologic...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Li, Hongyu, Valkenier, Hennie, Thorne, Abigail G., Dias, Christopher M., Cooper, James A., Kieffer, Marion, Busschaert, Nathalie, Gale, Philip A., Sheppard, David N., Davis, Anthony P.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984391/
https://ncbi.nlm.nih.gov/pubmed/32055336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc04242c
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