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Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs

Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial anion carriers (anionophores). Here, we screened 22 anionophores for biologic...

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Détails bibliographiques
Publié dans:Chem Sci
Auteurs principaux: Li, Hongyu, Valkenier, Hennie, Thorne, Abigail G., Dias, Christopher M., Cooper, James A., Kieffer, Marion, Busschaert, Nathalie, Gale, Philip A., Sheppard, David N., Davis, Anthony P.
Format: Artigo
Langue:Inglês
Publié: Royal Society of Chemistry 2019
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984391/
https://ncbi.nlm.nih.gov/pubmed/32055336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc04242c
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