Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs

Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial anion carriers (anionophores). Here, we screened 22 anionophores for biologic...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Li, Hongyu, Valkenier, Hennie, Thorne, Abigail G., Dias, Christopher M., Cooper, James A., Kieffer, Marion, Busschaert, Nathalie, Gale, Philip A., Sheppard, David N., Davis, Anthony P.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2019
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984391/
https://ncbi.nlm.nih.gov/pubmed/32055336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc04242c
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