The Genetic Background Modulates the Evolution of Fluoroquinolone-Resistance in Mycobacterium tuberculosis

Fluoroquinolones (FQ) form the backbone in experimental treatment regimens against drug-susceptible tuberculosis. However, little is known on whether the genetic variation present in natural populations of Mycobacterium tuberculosis (Mtb) affects the evolution of FQ-resistance (FQ-R). To investigate...

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Bibliografiske detaljer
Udgivet i:Mol Biol Evol
Main Authors: Castro, Rhastin A D, Ross, Amanda, Kamwela, Lujeko, Reinhard, Miriam, Loiseau, Chloé, Feldmann, Julia, Borrell, Sonia, Trauner, Andrej, Gagneux, Sebastien
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Discoveries
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984360/
https://ncbi.nlm.nih.gov/pubmed/31532481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msz214
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