FTO controls reversible m(6)Am RNA methylation during snRNA biogenesis

Small nuclear RNAs (snRNAs) are core spliceosome components and mediate pre-mRNA splicing. Here we show that snRNAs contain a regulated and reversible nucleotide modification causing them to exist as two different methyl isoforms, m(1) and m(2), reflecting the methylation state of the adenosine adja...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Mauer, Jan, Sindelar, Miriam, Despic, Vladimir, Guez, Théo, Hawley, Ben R., Vasseur, Jean-Jacques, Rentmeister, Andrea, Gross, Steven S., Pellizzoni, Livio, Debart, Françoise, Goodarzi, Hani, Jaffrey, Samie R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984009/
https://ncbi.nlm.nih.gov/pubmed/30778204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0231-8
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