Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

Phosphoinositides play crucial roles in intracellular membrane dynamics and cell signaling, with phosphatidylinositol (PI) 3-phosphates being the predominant phosphoinositide lipids at endosomes and lysosomes, whereas PI 4-phosphates, such as phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)), are...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Haibin, Loerke, Dinah, Bruns, Caroline, Müller, Rainer, Koch, Philipp-Alexander, Puchkov, Dmytro, Schultz, Carsten, Haucke, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983852/
https://ncbi.nlm.nih.gov/pubmed/31831620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011774
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