Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P(2)] is essential for exocytosis. Classical ways of manipulating PI(4,5)P(2) levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P(2) from those of its metabolites. We developed a membrane-permeant, photoactivatab...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Walter, Alexander M, Müller, Rainer, Tawfik, Bassam, Wierda, Keimpe DB, Pinheiro, Paulo S, Nadler, André, McCarthy, Anthony W, Ziomkiewicz, Iwona, Kruse, Martin, Reither, Gregor, Rettig, Jens, Lehmann, Martin, Haucke, Volker, Hille, Bertil, Schultz, Carsten, Sørensen, Jakob Balslev
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711374/
https://ncbi.nlm.nih.gov/pubmed/29068313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30203
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