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Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp

DNA clamp, a highly conserved ring-shaped protein, binds dsDNA within its central pore. Also, DNA clamp interacts with various nuclear proteins on its front, thereby stimulating their enzymatic activities and biological functions. It has been assumed that the DNA clamp is a functionally single-faced...

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Vydáno v:J Biol Chem
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983850/
https://ncbi.nlm.nih.gov/pubmed/31776186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.011816
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