Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex.

Methamphetamine (METH) and modafinil are psychostimulants with different long-term cognitive profiles: METH is addictive and leads to cognitive decline, whereas modafinil has little abuse liability and is a cognitive enhancer. Increasing evidence implicates epigenetic mechanisms of gene regulation b...

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Udgivet i:Prog Neuropsychopharmacol Biol Psychiatry
Main Authors: González, Betina, Jayanthi, Subramaniam, Gomez, Natalia, Torres, Oscar V., Sosa, Máximo H., Bernardi, Alejandra, Urbano, Francisco J., García-Rill, Edgar, Cadet, Jean-Lud, Bisagno, Verónica
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983674/
https://ncbi.nlm.nih.gov/pubmed/29247759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pnpbp.2017.12.009
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