Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex.

Methamphetamine (METH) and modafinil are psychostimulants with different long-term cognitive profiles: METH is addictive and leads to cognitive decline, whereas modafinil has little abuse liability and is a cognitive enhancer. Increasing evidence implicates epigenetic mechanisms of gene regulation b...

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Detalhes bibliográficos
Publicado no:Prog Neuropsychopharmacol Biol Psychiatry
Main Authors: González, Betina, Jayanthi, Subramaniam, Gomez, Natalia, Torres, Oscar V., Sosa, Máximo H., Bernardi, Alejandra, Urbano, Francisco J., García-Rill, Edgar, Cadet, Jean-Lud, Bisagno, Verónica
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983674/
https://ncbi.nlm.nih.gov/pubmed/29247759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pnpbp.2017.12.009
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