An anticancer gold(III)-activated porphyrin scaffold that covalently modifies protein cysteine thiols

Cysteine thiols of many cancer-associated proteins are attractive targets of anticancer agents. Herein, we unequivocally demonstrate a distinct thiol-targeting property of gold(III) mesoporphyrin IX dimethyl ester (AuMesoIX) and its anticancer activities. While the binding of cysteine thiols with me...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tong, Ka-Chung, Lok, Chun-Nam, Wan, Pui-Ki, Hu, Di, Fung, Yi Man Eva, Chang, Xiao-Yong, Huang, Song, Jiang, Haibo, Che, Chi-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983449/
https://ncbi.nlm.nih.gov/pubmed/31896586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915202117
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