Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids

Human noroviruses (HuNoVs) cause sporadic and epidemic outbreaks of gastroenteritis in all age groups worldwide. We previously reported that stem cell-derived human intestinal enteroid (HIE) cultures support replication of multiple HuNoV strains and that some strains (e.g., GII.3) replicate only in...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Murakami, Kosuke, Tenge, Victoria R., Karandikar, Umesh C., Lin, Shih-Ching, Ramani, Sasirekha, Ettayebi, Khalil, Crawford, Sue E., Zeng, Xi-Lei, Neill, Frederick H., Ayyar, B. Vijayalakshmi, Katayama, Kazuhiko, Graham, David Y., Bieberich, Erhard, Atmar, Robert L., Estes, Mary K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983410/
https://ncbi.nlm.nih.gov/pubmed/31896578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910138117
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