Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids

Human noroviruses (HuNoVs) are the leading cause of viral gastroenteritis worldwide; yet currently, no vaccines or FDA-approved antiviral drugs are available to counter these pathogens. To understand HuNoV biology and the epithelial response to infection, we performed transcriptomic analyses, RT-qPC...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Lin, Shih-Ching, Qu, Lin, Ettayebi, Khalil, Crawford, Sue E., Blutt, Sarah E., Robertson, Matthew J., Zeng, Xi-Lei, Tenge, Victoria R., Ayyar, B. Vijayalakshmi, Karandikar, Umesh C., Yu, Xiaomin, Coarfa, Cristian, Atmar, Robert L., Ramani, Sasirekha, Estes, Mary K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519316/
https://ncbi.nlm.nih.gov/pubmed/32907944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010834117
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