Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes

Primary human hepatocytes (PHHs) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan in culture, and resistance to genetic manipulation have limited their use. Here, we show that the pyrrolizidine alkaloid retrorsine improves P...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Michailidis, Eleftherios, Vercauteren, Koen, Mancio-Silva, Liliana, Andrus, Linda, Jahan, Cyprien, Ricardo-Lax, Inna, Zou, Chenhui, Kabbani, Mohammad, Park, Paul, Quirk, Corrine, Pyrgaki, Christina, Razooky, Brandon, Verhoye, Lieven, Zoluthkin, Irene, Lu, Wei-Yu, Forbes, Stuart J., Chiriboga, Luis, Theise, Neil D., Herzog, Roland W., Suemizu, Hiroshi, Schneider, William M., Shlomai, Amir, Meuleman, Philip, Bhatia, Sangeeta N., Rice, Charles M., de Jong, Ype P.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983380/
https://ncbi.nlm.nih.gov/pubmed/31915293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919035117
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