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Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes
Primary human hepatocytes (PHHs) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan in culture, and resistance to genetic manipulation have limited their use. Here, we show that the pyrrolizidine alkaloid retrorsine improves P...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6983380/ https://ncbi.nlm.nih.gov/pubmed/31915293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919035117 |
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