Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes

Primary human hepatocytes (PHHs) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan in culture, and resistance to genetic manipulation have limited their use. Here, we show that the pyrrolizidine alkaloid retrorsine improves P...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Michailidis, Eleftherios, Vercauteren, Koen, Mancio-Silva, Liliana, Andrus, Linda, Jahan, Cyprien, Ricardo-Lax, Inna, Zou, Chenhui, Kabbani, Mohammad, Park, Paul, Quirk, Corrine, Pyrgaki, Christina, Razooky, Brandon, Verhoye, Lieven, Zoluthkin, Irene, Lu, Wei-Yu, Forbes, Stuart J., Chiriboga, Luis, Theise, Neil D., Herzog, Roland W., Suemizu, Hiroshi, Schneider, William M., Shlomai, Amir, Meuleman, Philip, Bhatia, Sangeeta N., Rice, Charles M., de Jong, Ype P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983380/
https://ncbi.nlm.nih.gov/pubmed/31915293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919035117
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