Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in Streptococcus pneumoniae

Streptococcus pneumoniae is an opportunistic human pathogen that utilizes the competence regulon, a quorum-sensing circuitry, to acquire antibiotic resistance genes and initiate its attack on the human host. Interception of the competence regulon can therefore be utilized to study S. pneumoniae cell...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Yang, Yifang, Lin, Jingjun, Harrington, Anthony, Cornilescu, Gabriel, Lau, Gee W., Tal-Gan, Yftah
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983377/
https://ncbi.nlm.nih.gov/pubmed/31915298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915812117
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