Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3

We report on the design, synthesis and molecular modeling study of conjugates of adenosine diphosphate (ADP) and morpholino nucleosides as potential selective inhibitors of poly(ADP-ribose)polymerases-1, 2 and 3. Sixteen dinucleoside pyrophosphates containing natural heterocyclic bases as well as 5-...

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Publicat a:Int J Mol Sci
Autors principals: Sherstyuk, Yuliya V., Ivanisenko, Nikita V., Zakharenko, Alexandra L., Sukhanova, Maria V., Peshkov, Roman Y., Eltsov, Ilia V., Kutuzov, Mikhail M., Kurgina, Tatiana A., Belousova, Ekaterina A., Ivanisenko, Vladimir A., Lavrik, Olga I., Silnikov, Vladimir N., Abramova, Tatyana V.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982223/
https://ncbi.nlm.nih.gov/pubmed/31892271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010214
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