Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging

PARP1 and PARP2 are implicated in the synthesis of poly(ADP-ribose) (PAR) after detection of DNA damage. The specificity of PARP1 and PARP2 interaction with long DNA fragments containing single- and/or double-strand breaks (SSBs and DSBs) have been studied using atomic force microscopy (AFM) imaging...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Sukhanova, Maria V., Abrakhi, Sanae, Joshi, Vandana, Pastre, David, Kutuzov, Mikhail M., Anarbaev, Rashid O., Curmi, Patrick A., Hamon, Loic, Lavrik, Olga I.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824093/
https://ncbi.nlm.nih.gov/pubmed/26673720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1476
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