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Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels

Changes in fetal DNA methylation (DNAm) of the leptin (LEP) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear. We investigated the association between maternal hyperglycemia, placental LEP DNAm (25 5′-C-phosphate-G-3′ (Cp...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Int J Mol Sci
Päätekijät: Gagné-Ouellet, Valérie, Breton, Edith, Thibeault, Kathrine, Fortin, Carol-Ann, Cardenas, Andres, Guérin, Renée, Perron, Patrice, Hivert, Marie-France, Bouchard, Luigi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982090/
https://ncbi.nlm.nih.gov/pubmed/31947745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010329
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