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Folding Rate Optimization Promotes Frustrated Interactions in Entangled Protein Structures

Many native structures of proteins accomodate complex topological motifs such as knots, lassos, and other geometrical entanglements. How proteins can fold quickly even in the presence of such topological obstacles is a debated question in structural biology. Recently, the hypothesis that energetic f...

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Библиографические подробности
Опубликовано в: :Int J Mol Sci
Главные авторы: Norbiato, Federico, Seno, Flavio, Trovato, Antonio, Baiesi, Marco
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981561/
https://ncbi.nlm.nih.gov/pubmed/31892272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010213
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