African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

A variant at amino acid 47 in human TP53 exists predominantly in individuals of African descent. P47S human and mouse cells show increased cancer risk due to defective ferroptosis. Here, we show that this ferroptotic defect causes iron accumulation in P47S macrophages. This high iron content alters...

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Udgivet i:Nat Commun
Main Authors: Singh, Kumar Sachin, Leu, Julia I-Ju, Barnoud, Thibaut, Vonteddu, Prashanthi, Gnanapradeepan, Keerthana, Lin, Cindy, Liu, Qin, Barton, James C., Kossenkov, Andrew V., George, Donna L., Murphy, Maureen E., Dotiwala, Farokh
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981190/
https://ncbi.nlm.nih.gov/pubmed/31980600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14151-9
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