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Targeting glutamine metabolism slows soft tissue sarcoma growth

Tumour cells frequently utilize glutamine to meet bioenergetic and biosynthetic demands of rapid cell growth. However, glutamine dependence can be highly variable between in vitro and in vivo settings, based on surrounding microenvironments and complex adaptive responses to glutamine deprivation. So...

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Publicado en:Nat Commun
Autores principales: Lee, Pearl, Malik, Dania, Perkons, Nicholas, Huangyang, Peiwei, Khare, Sanika, Rhoades, Seth, Gong, Yao-Yu, Burrows, Michelle, Finan, Jennifer M., Nissim, Itzhak, Gade, Terence P. F., Weljie, Aalim M., Simon, M. Celeste
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981153/
https://ncbi.nlm.nih.gov/pubmed/31980651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14374-1
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