Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and whether human SAN excitability requires voltage-gated sodium channels (Nav) remains controversial. Here, we report that neuronal (n)Nav blockade and selective nNav1.6 blockade during high-resolution optical mapping in e...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Li, Ning, Kalyanasundaram, Anuradha, Hansen, Brian J., Artiga, Esthela J., Sharma, Roshan, Abudulwahed, Suhaib H., Helfrich, Katelynn M., Rozenberg, Galina, Wu, Pei-Jung, Zakharkin, Stanislav, Gyorke, Sandor, Janssen, Paul ML., Whitson, Bryan A., Mokadam, Nahush A., Biesiadecki, Brandon J., Accornero, Federica, Hummel, John D., Mohler, Peter J., Dobrzynski, Halina, Zhao, Jichao, Fedorov, Vadim V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981137/
https://ncbi.nlm.nih.gov/pubmed/31980605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14039-8
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