Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and whether human SAN excitability requires voltage-gated sodium channels (Nav) remains controversial. Here, we report that neuronal (n)Nav blockade and selective nNav1.6 blockade during high-resolution optical mapping in e...

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Pubblicato in:Nat Commun
Autori principali: Li, Ning, Kalyanasundaram, Anuradha, Hansen, Brian J., Artiga, Esthela J., Sharma, Roshan, Abudulwahed, Suhaib H., Helfrich, Katelynn M., Rozenberg, Galina, Wu, Pei-Jung, Zakharkin, Stanislav, Gyorke, Sandor, Janssen, Paul ML., Whitson, Bryan A., Mokadam, Nahush A., Biesiadecki, Brandon J., Accornero, Federica, Hummel, John D., Mohler, Peter J., Dobrzynski, Halina, Zhao, Jichao, Fedorov, Vadim V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981137/
https://ncbi.nlm.nih.gov/pubmed/31980605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14039-8
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