Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and whether human SAN excitability requires voltage-gated sodium channels (Nav) remains controversial. Here, we report that neuronal (n)Nav blockade and selective nNav1.6 blockade during high-resolution optical mapping in e...

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Publicado no:Nat Commun
Main Authors: Li, Ning, Kalyanasundaram, Anuradha, Hansen, Brian J., Artiga, Esthela J., Sharma, Roshan, Abudulwahed, Suhaib H., Helfrich, Katelynn M., Rozenberg, Galina, Wu, Pei-Jung, Zakharkin, Stanislav, Gyorke, Sandor, Janssen, Paul ML., Whitson, Bryan A., Mokadam, Nahush A., Biesiadecki, Brandon J., Accornero, Federica, Hummel, John D., Mohler, Peter J., Dobrzynski, Halina, Zhao, Jichao, Fedorov, Vadim V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981137/
https://ncbi.nlm.nih.gov/pubmed/31980605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14039-8
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