A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are characterized by increased protein aggregation in the brain, progressive neuronal loss, increased inflammation, and neurogenesis impairment. We analyzed the effects of a new purine derivative drug, PDD005, in attenuating...

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Pubblicato in:Sci Rep
Autori principali: Guyot, Anne-Cécile, Leuxe, Charlotte, Disdier, Clémence, Oumata, Nassima, Costa, Narciso, Roux, Gwenaëlle Le, Fernandez-Varela, Paloma, Duchon, Arnaud, Charbonnier, Jean Baptiste, Herault, Yann, Pavoni, Serena, Galons, Hervé, Andriambeloson, Emile, Wagner, Stéphanie, Meijer, Laurent, Lund, Amie K., Mabondzo, Aloïse
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981120/
https://ncbi.nlm.nih.gov/pubmed/31980673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57560-3
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