SUR1-TRPM4 channels, not K(ATP), mediate brain swelling following cerebral ischemia

BACKGROUND. Preclinical and emerging clinical data show that glibenclamide reduces space occupying edema and brain swelling following cerebral ischemia. Glibenclamide is a potent inhibitor of numerous sulfonylurea receptor (SUR)-regulated channels, including K(ATP) (SUR1-KIR6.2, SUR2A-KIR6.2, SUR2B-...

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Bibliographic Details
Published in:Neurosci Lett
Main Authors: Woo, Seung Kyoon, Tsymbalyuk, Natalia, Tsymbalyuk, Orest, Ivanova, Svetlana, Gerzanich, Volodymyr, Simard, J. Marc
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981040/
https://ncbi.nlm.nih.gov/pubmed/31899311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2019.134729
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