SUR1-TRPM4 channels, not K(ATP), mediate brain swelling following cerebral ischemia

BACKGROUND. Preclinical and emerging clinical data show that glibenclamide reduces space occupying edema and brain swelling following cerebral ischemia. Glibenclamide is a potent inhibitor of numerous sulfonylurea receptor (SUR)-regulated channels, including K(ATP) (SUR1-KIR6.2, SUR2A-KIR6.2, SUR2B-...

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Publicado en:Neurosci Lett
Autores principales: Woo, Seung Kyoon, Tsymbalyuk, Natalia, Tsymbalyuk, Orest, Ivanova, Svetlana, Gerzanich, Volodymyr, Simard, J. Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981040/
https://ncbi.nlm.nih.gov/pubmed/31899311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2019.134729
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