SUR1-TRPM4 channels, not K(ATP), mediate brain swelling following cerebral ischemia

BACKGROUND. Preclinical and emerging clinical data show that glibenclamide reduces space occupying edema and brain swelling following cerebral ischemia. Glibenclamide is a potent inhibitor of numerous sulfonylurea receptor (SUR)-regulated channels, including K(ATP) (SUR1-KIR6.2, SUR2A-KIR6.2, SUR2B-...

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Xehetasun bibliografikoak
Argitaratua izan da:Neurosci Lett
Egile Nagusiak: Woo, Seung Kyoon, Tsymbalyuk, Natalia, Tsymbalyuk, Orest, Ivanova, Svetlana, Gerzanich, Volodymyr, Simard, J. Marc
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981040/
https://ncbi.nlm.nih.gov/pubmed/31899311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2019.134729
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