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Single-domain antibodies for functional targeting of the signaling scaffold Shoc2

The accurate transmission of signals by the canonical ERK1/2 kinase pathway critically relies on the proper assembly of an intricate multiprotein complex by the scaffold protein Shoc2. However, the details of the mechanism by which Shoc2 guides ERK1/2 signals are not clear, in part, due to the lack...

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Detalhes bibliográficos
Publicado no:Mol Immunol
Main Authors: Jang, HyeIn, Wilson, Patricia G, Sau, Mary, Chawla, Udeep, Rodgers, David W, Galperin, Emilia
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981032/
https://ncbi.nlm.nih.gov/pubmed/31869742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2019.12.010
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