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Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells

Pluripotent stem cells recapitulate many aspects of embryogenesis in vitro. Here, we established a novel culture system to differentiate human embryonic stem cell aggregates (HESCA), and evaluated its utility for teratogenicity assessment. Culture of HESCA with modulators of developmental signals in...

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Sonraí Bibleagrafaíochta
Foilsithe in:Reprod Toxicol
Main Authors: Marikawa, Yusuke, Chen, Hong-Ru, Menor, Mark, Deng, Youping, Alarcon, Vernadeth B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980740/
https://ncbi.nlm.nih.gov/pubmed/31711903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2019.10.004
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