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Yap suppresses T-cell function and infiltration in the tumor microenvironment
A major challenge for cancer immunotherapy is sustaining T-cell activation and recruitment in immunosuppressive solid tumors. Here, we report that the levels of the Hippo pathway effector Yes-associated protein (Yap) are sharply induced upon the activation of cluster of differentiation 4 (CD4)-posit...
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| Publicado no: | PLoS Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980695/ https://ncbi.nlm.nih.gov/pubmed/31929526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000591 |
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