Yap suppresses T-cell function and infiltration in the tumor microenvironment

A major challenge for cancer immunotherapy is sustaining T-cell activation and recruitment in immunosuppressive solid tumors. Here, we report that the levels of the Hippo pathway effector Yes-associated protein (Yap) are sharply induced upon the activation of cluster of differentiation 4 (CD4)-posit...

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Veröffentlicht in:PLoS Biol
Hauptverfasser: Stampouloglou, Eleni, Cheng, Nan, Federico, Anthony, Slaby, Emily, Monti, Stefano, Szeto, Gregory L., Varelas, Xaralabos
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Short Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980695/
https://ncbi.nlm.nih.gov/pubmed/31929526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000591
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