Genomic profiling identifies association of IDH1/IDH2 mutation with longer relapse free and metastasis free survival in high-grade chondrosarcoma

PURPOSE: Chondrosarcomas are the second most common primary malignant bone tumors. While histologic grade is the most important factor predicting the clinical outcome of chondrosarcoma, it is subject to interobserver variability. IDH1 and IDH2 hotspot mutations were recently found to be frequently m...

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Bibliografiska uppgifter
I publikationen:Clin Cancer Res
Huvudupphovsmän: Zhu, Guo Gord, Nafa, Khedoudja, Agaram, Narasimhan P., Zehir, Ahmet, Benayed, Ryma, Sadowska, Justyna, Borsu, Laetitia, Kelly, Ciara, Tap, William D., Fabbri, Nicola, Athanasian, Edward, Boland, Patrick J., Healey, John H., Berger, Michael F., Ladanyi, Marc, Hameed, Meera R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980683/
https://ncbi.nlm.nih.gov/pubmed/31615936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-4212
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