Induction of sarcomas by mutant IDH2

More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Lu, Chao, Venneti, Sriram, Akalin, Altuna, Fang, Fang, Ward, Patrick S., DeMatteo, Raymond G., Intlekofer, Andrew M., Chen, Chong, Ye, Jiangbin, Hameed, Meera, Nafa, Khedoudja, Agaram, Narasimhan P., Cross, Justin R., Khanin, Raya, Mason, Christopher E., Healey, John H., Lowe, Scott W., Schwartz, Gary K., Melnick, Ari, Thompson, Craig B.
פורמט: Artigo
שפה:Inglês
יצא לאור: Cold Spring Harbor Laboratory Press 2013
נושאים:
Research Paper
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792475/
https://ncbi.nlm.nih.gov/pubmed/24065766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.226753.113
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