Induction of sarcomas by mutant IDH2

More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation...

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Detalhes bibliográficos
Main Authors: Lu, Chao, Venneti, Sriram, Akalin, Altuna, Fang, Fang, Ward, Patrick S., DeMatteo, Raymond G., Intlekofer, Andrew M., Chen, Chong, Ye, Jiangbin, Hameed, Meera, Nafa, Khedoudja, Agaram, Narasimhan P., Cross, Justin R., Khanin, Raya, Mason, Christopher E., Healey, John H., Lowe, Scott W., Schwartz, Gary K., Melnick, Ari, Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792475/
https://ncbi.nlm.nih.gov/pubmed/24065766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.226753.113
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