Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

The serine/threonine Protein Phosphatase 2A (PP2A) functions as a tumor suppressor by negatively regulating multiple oncogenic signaling pathways. The canonical PP2A holoenzyme is comprised of a scaffolding subunit (PP2A Aα/β), which serves as the platform for binding of both the catalytic C subunit...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: O’Connor, Caitlin M., Leonard, Daniel, Wiredja, Danica, Avelar, Rita A., Wang, Zhizhi, Schlatzer, Daniela, Bryson, Benjamin, Tokala, Eesha, Taylor, Sarah E., Upadhyay, Aditya, Sangodkar, Jaya, Gingras, Anne-Claude, Westermarck, Jukka, Xu, Wenqing, DiFeo, Analisa, Brautigan, David L., Haider, Shozeb, Jackson, Mark, Narla, Goutham
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980487/
https://ncbi.nlm.nih.gov/pubmed/31541192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1012-2
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