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Sevoflurane-induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain
BACKGROUND: The cation-chloride cotransporters Na(+)–K(+)–2Cl(−)–1 (NKCC1) and K(+)–2Cl(−)–2 (KCC2) critically regulate neuronal responses to gamma-aminobutyric acid (GABA). NKCC1 renders GABA excitatory in immature neurons while expression of KCC2 signals GABA maturation to its inhibitory role. Imb...
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| Izdano u: | Mol Neurobiol |
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| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980440/ https://ncbi.nlm.nih.gov/pubmed/31493242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-01751-1 |
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