Sevoflurane-induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain

BACKGROUND: The cation-chloride cotransporters Na(+)–K(+)–2Cl(−)–1 (NKCC1) and K(+)–2Cl(−)–2 (KCC2) critically regulate neuronal responses to gamma-aminobutyric acid (GABA). NKCC1 renders GABA excitatory in immature neurons while expression of KCC2 signals GABA maturation to its inhibitory role. Imb...

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Udgivet i:Mol Neurobiol
Main Authors: Cabrera, O. H., Tesic, V., Tat, Q. L., Chastain, S., Quillinan, N., Jevtovic-Todorovic, V.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980440/
https://ncbi.nlm.nih.gov/pubmed/31493242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-01751-1
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