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Phosphine-activated Lysine Analogues for Fast Chemical Control of Protein Subcellular Localization and Protein SUMOylation

The Staudinger reduction and its variants have exceptional compatibility with live cells, but can be limited by slow kinetics. Here, we report novel small molecule triggers that turn on proteins via a Staudinger reduction/self-immolation cascade with substantially improved kinetics and yields. We ac...

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Bibliografiske detaljer
Udgivet i:Chembiochem
Main Authors: Wesalo, Joshua S., Luo, Ji, Morihiro, Kunihiko, Liu, Jihe, Deiters, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980333/
https://ncbi.nlm.nih.gov/pubmed/31664790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900464
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